Max | Min | Average | LS fit | SD | |
---|---|---|---|---|---|

TET | |||||

A | 2.68 | 1.9 | 2.29 | 2.16 | 0.39 |

B | 1.02 | 1.37 | 1.20 | 1.15 | 0.18 |

DOX | |||||

A | 4.84 | 4.18 | 4.51 | 4.55 | 0.33 |

B | 1.32 | 1.46 | 1.39 | 1.34 | 0.07 |

MCN | |||||

A | 6.67 | 6.25 | 6.46 | 6.44 | 0.21 |

B | 2.03 | 2.36 | 2.20 | 2.18 | 0.17 |

The values presented in this table were generated by a least squares (LS) fit of the average experimental fitness functions plotted in Fig 1. Parameter

*A*has units of μg/ml and corresponds to the cytoplasmic drug concentration, [*S*]_{C}, at which the normalized growth rate is half maximal. Parameter*A*can also roughly be interpreted as the apparent*K*_{d}of the drug to the ribosome in addition to all other intercellular drug interactions. Parameter*B*is the Hill coefficient that describes the shape of the dose–response curve in response to the antibiotic and is thus a highly complex lumped parameter that models essentially all aspects of cellular physiology as one variable.