Table 1. List of drugs used in this study and their targets
CompoundsAbbreviationTarget processSymbolDrug classMIC (μg/ml)
AmikacinAMKProtein synthesis, 30S Embedded Image Aminoglycoside4
GentamicinGENProtein synthesis, 30SAminoglycoside3
TobramycinTOBProtein synthesis, 30SAminoglycoside2.5
TetracyclineTETProtein synthesis, 30STetracycline18
ChloramphenicolCHLProtein synthesis, 50S Embedded Image "/> Phenylpropanoid5
ClarithromycinCLAProtein synthesis, 50SMacrolide22
ErythromycinERYProtein synthesis, 50SMacrolide13
CiprofloxacinCIPDNA gyrase Embedded Image Quinolone0.01
LevofloxacinLEVDNA gyraseQuinolone0.013
Nalidixic acidNALDNA gyraseQuinolone5
TrimethoprimTRIFolic acid biosynthesisPyrimidine0.35
OxacillinOXACell wall Embedded Image Beta‐lactam190
CefoxitinCEFCell wallBeta‐lactam4.5
H2O2H22Oxidative stress ROS Stress250
NitrofurantoinNITMultiple mechanismsFuran12
Fusidic acid FUSElongation factor—protein synthesis Embedded Image Fusidane800
Rifampicin RIFRNA synthesis Embedded Image Rifampin2.5
Vancomycin VANCell wallGlycopeptide180
Spectinomycin SPE30S protein synthesisAminocylitol5.6
  • The antibiotics used in the test set for validation are highlighted in italics.