Table 5. Top key drivers (KDs)
KDCellular networkTWASGWAS
KD P‐value, corrected for subnetwork sizeTissue / networkP‐valuea for BP TWASeSNP IDP‐valueb in ICBP GWASBP coEM
Top BP GWAS KDs
 SH2B3 4.4e‐4HPRDrs6531781.6e‐14Turquoise
 ATXN2 c 2.2e‐5HPRDrs37420042.2e‐8Turquoise
 NMT1 1.6e‐5HPRDrs129464548.9e‐8Turquoise
 NSF 5.0e‐9HPRDrs176087667.3e‐7Turquoise
 HSPA1B 2.1e‐9HPRDrs8053031.3e‐6Blue
 BAT2 5.4e‐7HPRDrs805303d1.3e‐6Turquoise
 MAPKAPK5 c 2.8e‐8HPRDrs47672931.5e‐6Turquoise
Top BP TWAS KDs
 GZMB c 2.0e‐23Blood4.8e‐22Chocolate
 PRF1 2.0e‐26Blood2.5e‐9Chocolate
 GPR56 1.2e‐26Blood3.5e‐9Chocolate
 RAB11FIP1 1.3e‐3Blood4.0e‐8Turquoise
 HIPK1 c 3.1e‐8HPRD9.1e‐8Turquoise
 GZMH c 5.4e‐24Blood3.3e‐7Chocolate
 VIM 6.0e‐3HPRD4.2e‐7Turquoise
 BCL2L11 c 1.8e‐10HPRD1.7e‐6Blue
 BHLHE40 c 3.8e‐7HPRD2.2e‐6Turquoise
 KLRD1 1.2e‐30Blood2.5e‐6Chocolate
 TGFBR3 1.1e‐26Blood2.5e‐6Chocolate
Top multi‐tissue/ network KDs
 DCLRE1C c 1.1e‐16HPRD, BloodBlue
 ERCC6 8.8e‐14HPRD, BloodTurquoise
  • a P‐values passing transcriptome‐wide significance at Bonferroni‐corrected < 0.05 (corrected for 17,318 measured genes).

  • b Minimum P‐values for SBP, DBP, and HTN associations.

  • c Indicating the KD could be replicated in BioGrid PPI database (Chatr‐Aryamontri et al, 2013).

  • d trans‐eSNP; other eSNPs are cis‐eSNPs.

  • PPI, protein–protein interaction; HPRD, Human Protein Reference Database (Keshava Prasad et al, 2009).