Table 2. Novel functions represented by selected genes from 333 DEGs (differentially expressed genes) shared by five mouse–prion combinations
CategoryGene symbolaDescriptionEntrez IDPrevious studiesbHuman orthologsc
Leukocyte extravasationCsf1*Colony‐stimulating factor 1 (macrophage)12977CSF1
Prg1*Proteoglycan 1, secretory granule19073SRGN
Selpl*Selectin, platelet (p‐selectin) ligand20345SELPLG
CybaCytochrome b‐245, alpha polypeptide13057R, X4CYBA
ItgaxIntegrin alpha X16411R, X4ITGAX
MsnMoesin17698R, X4MSN
Androgen metabolismCyp7b1*Cytochrome P450, family 7, subfamily b, polypeptide 113123CYP7B1
Hsd3b7*Hydroxy‐delta‐5‐steroid dehydrogenase, 3 beta‐ and steroid delta‐isomerase 7101502HSD3B7
Slco2b1*Solute carrier organic anion transporter family, member 2b1101488SLCO2B1
BzrpBenzodiazepine receptor, peripheral12257XTSPO
DbiDiazepam‐binding inhibitor13167S, Sk, BoDBI
Iron homeostasis and heme metabolismCp*Ceruloplasmin12870CP
Slc39a14*Solute carrier family 39 (zinc transporter), member 14213053SLC39A14
Ftl1Ferritin light chain 114325SkFTL
TrfTransferrin22041Sk, BoTF
Demyelination, neurogenesis, axonal transport, ion channelsKif5c*Kinesin family member 5C16574KIF5C
Lgi4*Leucine‐rich repeat LGI family, member 4243914LGI4
Nupr1*Nuclear protein 156312NUPR1
P2rx7*Purinergic receptor P2X, ligand‐gated ion channel, 718439P2RX7
Scn1a*Sodium channel, voltage‐gated, type I, alpha20265SCN1A
Arachidonate/phospholipid metabolism and calcium signaling pathwayAlox5ap*Arachidonate 5‐lipoxygenase‐activating protein11690ALOX5AP
Cyp4f14*Cytochrome P450, family 4, subfamily f, polypeptide 1464385CYP4F2
Ptgs1*Prostaglandin‐endoperoxide synthase 119224PTGS1
HpgdHydroxyprostaglandin dehydrogenase 15 (NAD)15446Bo, RHPGD
Plce1*Phospholipase C, epsilon 174055PLCE1
Adcy7*Adenylate cyclase 711513ADCY7
HematopoiesisGmfg*Glia maturation factor, gamma63986GMFG
Inpp5dInositol polyphosphate‐5‐phosphatase D16331XINPP5D
Lcp1Lymphocyte cytosolic protein 118826X4LCP1
Nckap1lNCK‐associated protein 1 like105855XNCKAP1L
Old gene symbolsdUpdated gene symbolDescriptionEntrez ID
BzrpTspoTranslocator protein12257
SelplSelplgSelectin, platelet (p‐selectin) ligand20345
  • a Genes with asterisk are unique DEGs to this study; genes in bold and italic show decreased expression in infected mouse brains.

  • b S (Sorensen et al, 2008); X (Xiang et al, 2007); Sk (Skinner et al, 2006); Br (Brown et al, 2005); Bo (Booth et al, 2004); R (Riemer et al, 2004); X4 (Xiang et al, 2004).

  • c Orthologous human gene symbols are current as of 28 August 2008.

  • d Gene symbols have been updated in the EntrezGene database as of 28 August 2008.