Signaling branching type | Signaling convergence type | |||
---|---|---|---|---|

Increasing | Decreasing | Increasing | Decreasing | |

Activating group | 676 | 551 | 1032 | 418 |

Inhibitory group | 46 | 140 | 93 | 96 |

Odds ratio | 3.7 | 2.5 | ||

P‐value | 3.7 × 10^{−15} | 2.5 × 10^{−9} |

For each signaling flow type, we classified the units into two groups: activating group and inhibitory group. For each group, we compared the mutation frequencies of an upstream node with that of the downstream node. ‘Increasing’ represents that the mutation frequency of a downstream node is higher than that of an upstream node, whereas ‘decreasing’ represents that the mutation frequency of a downstream node is lower than that of an upstream node. Odds ratio was calculated by (increasing, activating group) × (decreasing, inhibitory group)/(increasing, inhibitory group)/(decreasing, activating group).

*P*‐value was calculated by Fisher‧s exact test.