Table 1. Effects of the positive and negative signals on the oncogene‐signaling flows
Signaling branching typeSignaling convergence type
IncreasingDecreasingIncreasingDecreasing
Activating group6765511032418
Inhibitory group461409396
Odds ratio3.72.5
P‐value3.7 × 10−152.5 × 10−9
  • For each signaling flow type, we classified the units into two groups: activating group and inhibitory group. For each group, we compared the mutation frequencies of an upstream node with that of the downstream node. ‘Increasing’ represents that the mutation frequency of a downstream node is higher than that of an upstream node, whereas ‘decreasing’ represents that the mutation frequency of a downstream node is lower than that of an upstream node. Odds ratio was calculated by (increasing, activating group) × (decreasing, inhibitory group)/(increasing, inhibitory group)/(decreasing, activating group). P‐value was calculated by Fisher‧s exact test.