Table 4. Target genes of HNF‐1 in liver
Gene nameAnnotationPWM scoreExpression log ratioEvidence for direct targets
Adult liverFetal liverHNF‐1 binding P‐valueExperimental evidence (PubMed ID)
ALBAlbumin0.48735.074.272.3 × 10−72693890
FGBFibrinogen, B beta polypeptide0.48494.374.898218230
AFPAlpha‐fetoprotein0.4630−1.095.810.72479822
CYP2E1Cytochrome P450, family 2, subfamily E, polypeptide 10.46225.93−1.898.1 × 10−97710685
GCGroup‐specific component (vitamin D binding protein)0.45924.864.490.89774468
FGAFibrinogen, A alpha polypeptide0.45824.254.327499335
GARSGlycyl‐tRNA synthetase0.4569−2.16−0.954.1 × 10−5
APOHApolipoprotein H0.45335.324.775.0 × 10−814984368
TXNIPThioredoxin interacting protein0.4523−0.96−2.170.1
RPL34Ribosomal protein L34, transcript variant 10.4521−2.70−1.330.7
  • Characteristics of the predicted targets of HNF‐1 among 1000 modeled genes under the given experimental condition. Expression data are log2(Eg/EgC), where Eg is the observed expression level of gene g and EgC is that of the average across all the tissues. In all cases, the mRNA levels change by at least two‐fold in adult liver, and also in fetal liver, suggesting liver‐specific activity. HNF‐1 binding P‐values were obtained from Odom et al (2004): P⩽0.001 indicates strong binding. We find evidence for eight of the 10 predicted targets as being direct HNF‐1 targets: ALB, FGB, AFP, CYP2E1, GC, FGA, GARS and APOH. The detailed references for reported experimental evidence in the last column are given in Supplementary Table VI.