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Editors & Advisory Editorial Board

Editors
Senior Editors
Advisory Editorial Board

 

Editorial Team

Thomas Lemberger (Chief Editor)

Thomas completed his PhD at the University of Lausanne, where he studied hormonal regulation of gene expression by nuclear receptors. He moved then to Heidelberg where his research focused on the regulation of transcription in the brain.

msb@embo.org
tel: +49 6221 8891 413

Maria Polychronidou (Scientific Editor)

Maria received her PhD from the University of Heidelberg, where she studied the role of nuclear membrane proteins in development and aging. During her post-doctoral work, she focused on the analysis of tissue-specific regulatory functions of Hox transcription factors using a combination of computational and genome-wide methods.

msb@embo.org
tel: +49 6221 8891 410

 

Journal Staff

Jana Christopher - Editorial Assistant, Data Integrity Analyst
Uta Mackensen - Graphics Editor
Sandra Krahl - Graphics Editor

 

Wiley Editorial Staff

Cate Livingstone - Executive Editor, Global Research, Wiley
Georgi Hristov - Assistant Editor, EMBO Press
Rebekka Mindnich - Assistant Editor, EMBO Press
Vivian Killet - Assistant Editor, EMBO Press

 

Senior Editors

Senior Editor: Ruedi Aebersold

Ruedi Aebersold is a founding member of the Institute for Systems Biology in Seattle, Washington, where he has led the proteomics program of the Institute. The program is focused on developing new methods and technologies for quantitative proteomics and for applying this emerging technology to enhance our understanding of the structure, function, and control of complex biological systems. In November 2004, he assumed an appointment at ETH-Zurich and the University of Zurich, Switzerland, as Professor of Systems Biology.

Senior Editor: Peer Bork

Peer Bork is joint coordinator of the Structural and Computational Biology programme at EMBL and also holds an appointment at the Max-Delbrueck Center for Molecular Medicine in Berlin. He is a computational biologist and has worked on various aspects of function prediction.

Senior Editor: George Church

George Church is Professor of Genetics at Harvard Medical School and Director of the Center for Computational Genetics. With degrees from Duke University in Chemistry and Zoology, his PhD from Harvard in Biochemistry & Molecular Biology with Walter Gilbert included the first direct genomic sequencing method in 1984. He invented the broadly-applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. His current research focuses on integrating biosystems-modeling with personal genomics & synthetic biology.

Senior Editor: Leroy Hood

Leroy Hood is recognized as one of the world’s leading scientists in molecular biotechnology and genomics. A passionate and dedicated researcher, he holds numerous patents and awards for his scientific breakthroughs and prides himself on his life-long commitment to making science accessible and understandable to the general public. In 2000, Dr. Hood co-founded the Institute for Systems Biology in Seattle, Washington to pioneer systems approaches to biology and medicine. He serves as President of the Institute and continues to pursue his interest in biology, medicine, technology, development, and computational biology.

Senior Editor: Edison Liu

Edison Liu is Executive Director of The Genome Institute of Singapore. Recognized as a top breast cancer researcher, Dr Liu was a pioneer in using an integrated investigative approach to decipher the biology of human breast cancers and to the discovery of clinically useful biomarkers. His gene-discovery strategy identified novel kinases and gene cassettes involved in maintaining the cancer phenotype. His recent work centers on the expression genomics of human cancers and the use of transcription genetics in deciphering cryptic signaling pathways.

Advisory Editorial Board

Julie Ahringer is a Group leader at the Gurdon Institute at the University of Cambridge. Her laboratory carried out the first systematic inactivation of the majority of genes in the nematode C. elegans through use of a genome-wide RNA interference library. She continues to use genomic approaches to study different biological processes, including transcriptional regulation, cell polarity, and genome evolution.

Charles Auffray is Research Director at CNRS, heads the Genexpress team in Functional Genomics and Systems Biology for Health in Villejuif, France. He has interests in the physio-pathology of the immune and neuro-muscular systems and cancer by integrating biochemistry, cellular and molecular biology together with mathematical, statistical and computational approaches.

Johan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland. He uses cross-species systems genetics and physiology to understand metabolism in health, aging and disease. Much of his work focused on understanding how genetic and environmental factors, such as diet, exercise and hormones, control mitochondrial metabolism through modulating the activity of transcription factors and their associated coregulators.

Gary Bader is Associate Professor, Molecular Genetics and Computer Science at The Donnelly Centre, University of Toronto. His research is focused on interpreting genomic data using biological pathways to gain a better understanding of cellular function. This is supported by extensive protein interaction prediction and pathway and network database projects.

Ewan Birney is a Team Leader at the European Bioinformatics Institute, head of Genome Annotation and a Senior Scientist at EMBL. He runs the EBI side of the Ensembl project, a software system that annotates and displays vertebrate genomes. He is also a key figure in the development of the Reactome project.

Tom Blundell is Sir William Dunn Professor of Biochemistry at the University of Cambridge. His research interests are in the molecular architecture of living organisms, with an emphasis on growth factors, receptor activation and signal transduction, important in cancer and other diseases.

Michael Boutros is a Group leader at the German Cancer Research Center (DKFZ) and Professor at Heidelberg University. His research interests are in systems genetics, in particular with relation to cellular signaling in developmental biology and cancer. His group uses large-scale functional approaches to dissect genotype to phenotype relationships.

Thomas S. Deisboeck is Assistant Professor of Radiology at Harvard Medical School and Director of the Complex Biosystems Modeling Laboratory at the Harvard-MIT (HST) Martinos Center for Biomedical Imaging at Massachusetts General Hospital. His primary research interest is the interdisciplinary modeling of cancer biology.

Jan Ellenberg is a group leader at the EMBL in Heidelberg. His research group works on the functional dynamics of nuclear structure during the cell cycle combining advanced quantitative fluorescence microscopy approaches and computer simulations of biological processes.

Michael Elowitz is Assistant Professor, biology and applied physics at Caltech. His team is interested in how genetic circuits operate and evolve in living cells. Using experimental and theoretical approaches, the group studies the behaviour of simple genetic elements, and the circuits they comprise, at the single cell level.

James Ferrell is Professor and Chair of Chemical and Systems Biology at Stanford University School of Medicine. His research focuses on the design principles of signaling systems, particularly the cell cycle.

Alan Fersht is Director of the MRC Centre for Protein Engineering and Professor of Organic Chemistry in the University of Cambridge. His major research interests are in the structure, function and folding of proteins and their misfolding and instability in cancer and other diseases.

Stan Fields is an investigator of the Howard Hughes Medical Institute and a Professor in the Department of Genome Sciences and the Department of Medicine at the University of Washington in Seattle. His laboratory works on technologies to analyze protein function, especially on a proteome-wide basis, including methods to detect the interactions of proteins with other macromolecules. The laboratory also uses yeast to study proteins relevant to human biology, including aging-associated proteins and proteins encoded by the major malaria pathogen.

Eileen Furlong is joint head of the Genome Biology unit at EMBL, Heidelberg. Her research interests focus on transcriptional networks during development. For this purpose, her group combines genomic, genetic and bioinformatic approaches to gain predictive insights into developmental progression.

Anne-Claude Gavin is group leader and senior scientist at the European Molecular Biology Laboratory (EMBL) in Heidelberg - Structural and Computational Biology Unit. Her group integrate biochemical, mass spectrometry, structural and computational methods to characterize cellular networks and circuitry at molecular levels, both spatially and temporally. Her research aims at understanding how cellular components work collectively and achieve biological function.

Ronald Germain is Chief of the Lymphocyte Biology Section, Laboratory of Immunology and Director of the Program in Systems Immunology and Infectious Disease Modeling at the National Institute of Allergy and Infectious Diseases, NIH, USA, as well as Associate Director, Trans-NIH Center for Human Immunology. His primary research interests are in the workings of the immune systems at multiple scales of biological resolution and the use of imaging and computational approaches in advancing our understanding of immune processes.

Mark Gerstein is the Albert L Williams Associate Professor of Biomedical Informatics at Yale University. He is co-director the Yale Computational Biology and Bioinformatics Program. His research is focused on bioinformatics, and he is particularly interested in large-scale integrative surveys, biological database design, macromolecular geometry, molecular simulation, human genome annotation, gene expression analysis, and data mining.

Anne-Claude Gingras is a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto and an Associate Professor in the Department of Molecular Genetics at the University of Toronto. Her research focuses on the study of signalling pathways using systematic approaches and on the development of quantitative proteomics technologies, both experimental and computational.

Frank Holstege is head of the Genomics Laboratory at the University Medical Center Utrecht in the Netherlands. The laboratory has interests in mechanisms of eukaryotic transcription regulation. It combines a microarray facility and technology group with a bioinformatics group that is engaged in mining of DNA microarray data and integrative analyses of genome-scale datasets.

Laurence D. Hurst is the Professor of Evolutionary Genetics at The University of Bath, U.K.. Employing bioinformatic, comparative genomic and systems biological tools, his research interests concern how genes and genomes evolve. In particular, his work focuses on understanding gene order evolution, why most genes appear to be dispensable and why synonymous mutations are under selection.

Trey Ideker is Professor of Medicine and Bioengineering at the University of California at San Diego. He serves as Division Chief of Medical Genetics, Director of the National Resource for Network Biology and Director of the San Diego Center for Systems Biology, as well as being Adjunct Professor of Computer Science and Member of the Moores UCSD Cancer Center. He is a pioneer in assembling genome-scale measurements to construct network models of cellular processes and disease. His recent research activities include assembly of networks governing the response to DNA damage; development of the Cytoscape and NetworkBLAST software packages for biological network visualization and cross-species network comparison; and methods for identifying network-based biomarkers in development and disease.

Dirk Inzé is full professor in Plant Physiology and Plant Molecular Biology at Ghent University and Director of the Department of Plant Systems Biology of VIB (Flanders Institute for Biotechnology). Dirk Inzé’s research ambition is to decipher the complex molecular networks regulating plant organ growth and crop productivity.

Sung Hou Kim is Director of Calvin Laboratory, UCB, the Head of the Berkeley Structural Genomics Center, LBNL, and Head of the Structural Biology Department, Physical Biosciences Division, LBNL. His research interests are in combining biophysical, biochemical and computational genomics approaches to understand structure-function relationship and folding principles of proteins at the molecular and genomic levels.

Boris Kholodenko is the Science Foundation Ireland Stokes Professor of Systems Biology, Deputy Director of Systems Biology Ireland, University College Dublin and Adjunct Professor at Thomas Jefferson University, Philadelphia, USA. He studies are aimed to understand cellular information transfer and cell-fate decisions governed by the spatiotemporal dynamics of signaling and gene networks.

Hiroaki Kitano is director of Sony Computer Science Laboratories, Inc. and Director of the Systems Biology Institute, Tokyo Japan. His recent research interests concern biological robustness, cancer systems biology, software platforms for systems biology and robotics.

Jan Korbel is group leader at the EMBL in Heidelberg and at EMBL-EBI in Hinxton. His group is investigating the mutational origins and functional consequences of genetic variation, with a special focus on genomic structural variation using experimental and computational approaches in molecular genetics and genomics. His interests range from germline genetics to somatic DNA alterations occurring in cancer, and one main research objective is to dissect the mechanistic basis of DNA alteration processes associated with disease.

Nevan J. Krogan is Professor of Cellular & Molecular Pharmacology at the University of California-San Francisco, and Director of the California Institute for Quantitative Biosciences at UCSF. He holds affiliated appointments at the Helen Diller Family Comprehensive Cancer Center at UCSF, and the Gladstone Institutes for Cardiovascular Disease and Virology & Immunology. Dr. Krogan is an expert in the fields of functional genomics and systems biology. His lab is now developing a “systems to mechanism” approach to biology, applying global proteomic and genomic techniques to study various biological processes, notably the functional interface between pathogenic organisms and their hosts. Ultimately, this approach will provide insight into host pathways that are routinely hijacked and re-wired, providing a clearer vision of where future efforts for therapeutic intervention should take place

Galit Lahav is an Associate Professor of Systems Biology at Harvard Medical School. Her lab combines quantitative live-cell imaging and mathematical modeling to study the dynamics of signaling networks in human cells in order to understand cellular decision-making in individual cancer and healthy cells

Doron Lancet is Professor in the Department of Molecular Genetics, and Director of Israel’s National Center for Genomics. He discovered the molecular basis of smell transduction, and currently studies the genomics and population genetics of human olfaction. He developed GeneCards, a widely used web-based gene compendium, and does research in proteomics, transcriptomics, medical genetics and prebiotic evolution.

Andrew J. Link is an Ingram Assistant Professor of Cancer Research in the Department of Microbiology and Immunology at Vanderbilt University School of Medicine in Nashville, TN. His research focuses on the application of mass spectrometry-based proteomics to biological problems and his interests include protein translation, transcription, protein interactions, and technology development.

Rune Linding is Professor at the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen (UCPH). His lab is a network biology research group that explore biological systems by developing and deploying algorithms on quantitative global cell signaling data. The longterm aim is to forecast cell behavior with an accuracy similar to that of weather or aircraft models and use this capability to target complex diseases such as cancer.

Andrew Millar holds a Chair of Systems Biology at the University of Edinburgh. He studied Genetics at Cambridge University, then gained his Ph.D. at The Rockefeller University, New York, studying the 24-hour biological clock. His laboratory combines experiments, bioinformatics and mathematical modelling in order to understand daily and seasonal rhythms in plants and algae.

Vamsi Mootha is a Professor of Systems Biology and Medicine at Harvard Medical School and Massachusetts General Hospital. His laboratory utilizes genomics, biochemistry, and systems biology to study mitochondria and inborn errors of metabolism.

Jeremy Nicholson is Professor and Head of Biological Chemistry at Imperial College, London University. His research interests include: biological NMR spectroscopy, novel LC-MS and electrochemical approaches to bioanalysis, chemometrics, metabolic modelling and studies leading to the understanding the molecular basis of disease and toxic processes.

Garry Nolan is Professor of Microbiology & Immunology at the Stanford University School of Medicine. His group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology, bacterial pathogens as well as understanding normal immune system function. Using advanced flow cytometric techniques— including a new hybrid mass spectrometer/flow cytometer that allows for as many as 50 – 100 epitope-specific parameters to be measured per cell— and computational biology approaches, the team focuses on high throughput drug screening, mouse models of disease, and application of this approaches to primary patient materials from clinical trials for disease management and understanding disease processes at the single cell level.

Béla Novák is the Professor of Systems Biology at the Oxford Centre for Integrative Systems Biology, Department of Biochemistry of University Oxford. His research group is interested in the dynamics of intracellular signal transduction networks like the one that controls cell cycle progression in eukaryotes.

Duncan Odom obtained his PhD in bioinorganic chemistry from the California Institute of Technology in 2001. He was a postdoctoral fellow at the Whitehead Institute / MIT until 2006, after which he moved to the University of Cambridge, Cancer Research UK – Cambridge Institute. Since 2011, he has also been an Associate Faculty member at the Wellcome Trust Sanger Institute.

Stephen Oliver is Professor at the Department of Biochemistry and Director of the Cambridge Systems Biology Centre at the University of Cambridge. His research interests focus on the molecular genetics of yeasts and fungi, functional genomics and genome evolution.

Alexander van Oudenaarden is the Director of the Hubrecht Institute for Developmental Biology and Stem Cell Research in Utrecht. The van Oudenaarden lab is using a combination of experimental, computational, and theoretical approaches to quantitatively understand decision-making in single cells with a focus on questions in developmental and stem cell biology.

Bernhard Palsson is Professor of Bioengineering and Adjunct Professor Medicine at the University of California, San Diego. His current research at UCSD focuses on the reconstruction of genome-scale biochemical reaction networks, the development of mathematical analysis procedures for genome-scale models, and the experimental verification of genome-scale models with current emphasis on cellular metabolism and transcriptional regulation in E. coli and yeast.

Norbert Perrimon is Professor of Genetics at Harvard Medical School and an Investigator of the Howard Hughes Medical Institute. Over the years, Perrimon and his colleagues have made a number of contributions to our understanding of the structure of signal transduction pathways. In addition, his laboratory has developed a number of techniques that have proven useful to identify gene functions. Recently, most of his efforts have focused on applying the RNA interference methodology to high-throughput screening in Drosophila cells and in vivo with the ultimate goal to study genetic redundancy in biological networks.

Joshua Rabinowitz is Professor of Chemistry and Integrative Genomics at Princeton University. His lab develops technologies for measuring cellular metabolites and their fluxes, and combines these “metabolomic” approaches with quantitative modeling to understand cellular and tissue metabolism, including its normal regulation and its dysregulation in disease.

Nikolaus Rajewsky is Scientific Head of the "Berlin Institute for Medical Systems Biology since 2008. His lab combines theoretical/computational and experimental methods to understand more about gene regulation in animals. Research teams are interdisciplinary, employing techniques from molecular biology and biochemistry on different model organisms and driving the analysis with tools and concepts from bioinformatics, statistics, and physics. A major focus is on post-transcriptional gene regulation by small RNAs and RNA binding proteins.

Rama Ranganathan is HHMI Investigator and Associate Professor of Pharmacology at The University of Texas Southwestern Medical Center at Dallas. He is interested in understanding the structural principles of function in cellular signaling systems and how these systems are built through the process of evolution.

Aviv Regev received her Ph.D. in computational biology from Tel Aviv University. She joined the Broad Institute as a core member, and MIT as a faculty member in 2006, and has been an Early Career Scientist at the Howard Hughes Medical Institute since 2009. Regev’s research centers on understanding how complex molecular networks function and evolve in the face of genetic and environmental changes, over time-scales ranging from minutes to millions of years. Prior to joining the Broad Institute, Regev was a fellow at the Bauer Center for Genomics Research at Harvard University, where she developed new approaches to the reconstruction of regulatory networks and modules from genomic data.

Uwe Sauer is Professor of Systems Biology at the ETH Zurich. His research interests focus on complex metabolic and regulation networks in bacteria and yeast. For this purpose, his group develops methods for 13C-flux analysis and metabolomics, both for quantitative and high throughput analyses, that are combined with computational models.

Eric Schadt is Chief Scientific Officer at Pacific Bioscience where he oversees the scientific strategy for the company, including creating the vision for next-generation sequencing applications of the company’s technology. He is also a founding member of Sage Bionetworks, an open access genomics initiative designed to build and support databases and an accessible platform for creating innovative, dynamic models of disease.

Luis Serrano is Head of the Structural and Computational Biology Unit at the EMBL, Heidelberg. His research group is investigating how to combine protein structural information with protein design algorithms to predict protein-protein and protein-dna interactions.

Lucy Shapiro is Ludwig Professor of Cancer Research in the Department of Developmental Biology at the Stanford University School of Medicine and the Director of the Beckman Center for Molecular and Genetic Medicine at Stanford. The focus of her work is the genetic circuitry that controls the progression of the cell cycle and the 3 D deployment of regulatory proteins that coordinates the cell cycle regulatory network.

Benny Shilo is a group leader in the Department of Molecular Genetics, at the Weizmann Institute, Israel. Following his discovery of proto-oncogene homologues in Drosophila, his lab has focused on dissection of developmental signaling pathways. For the past decade he has also been involved in collaborations with computational biologists aimed at understanding the basis for robustness and scaling during development.

Pamela Silver is Professor of Systems Biology at Harvard Medical School and the Director of the Harvard University-wide PhD Program in Systems Biology. She is also a member of the Department of Cancer Biology at the Dana Farber Cancer Institute. Her research interests include the systems biology of RNA, understanding the dynamics of intranuclear networks, using cell-based screens for pathway discovery, and synthetic biology to design eukaryotic cells.

Christina Smolke is an Assistant Professor in the Department of Bioengineering at Stanford University. She is also a member of the Cancer Immunotherapeutics Program at the City of Hope. Her research program focuses on the design of RNA-based information processing and control devices, and their integration into cellular computation, signal processing, and systems-level engineering strategies.

Michael Snyder is the Stanford Ascherman Professor and Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine. His laboratory study was the first to carry out a large-scale functional genomics project in any organism, and currently carries out a variety of projects in the areas of genomics and proteomics both in yeast and humans.

Peter Sorger is Professor of Systems Biology at Harvard Medical School and Biological Engineering at MIT and received his Ph.D. in 1993 from Trinity College Cambridge under the supervision of Hugh Pelham. Sorger then trained as a Markey Postdoctoral Fellow with Harold Varmus and Andrew Murray at UCSF. Sorger’s research focuses on modeling and measuring death and survival pathways in mice and humans and on chromosome segregation. He directs the Center for Cell Decision Processes (www.cdpcenter.org) and is cofounder of Merrimack Pharmaceuticals and Glencoe software.

Lars Steinmetz is a Professor of Genetics at Stanford University and the Associate Head of the Genome Biology Unit at the European Molecular Biology Laboratory (EMBL). His research focuses on developing and applying interdisciplinary, genome-wide technologies to investigate the function and mechanism of genome regulation, the genetic basis of complex phenotypes and the genetic and molecular systems underpinning disease.

Janet Thornton is Director of the EMBL - European Bioinformatics Institute on the Wellcome Trust Genome Campus at Hinxton, near Cambridge, on secondment from UCL/Birkbeck College London. She is an Honorary Professor in the Department of Chemistry, University of Cambridge. Her research focuses on the functions and interactions of proteins with other molecules in the cell from a structural perspective with the goal of improving rational drug design.

Masaru Tomita is a Professor and the Director of the Institute for Advanced Biosciences, Keio University, and a founder of Human Metabolome Technologies, Inc. He is the Principal Investigator of the e-CELL Project, which was founded in 1996 with the objective of modeling and simulating cellular metabolism. His research interests are bioinformatics, metabolomics, genome informatics and biological simulation.

Marc Vidal is an Associate Professor in Cancer Biology and the Director of the Center for Cancer Systems Biology at the Dana-Farber Cancer Institute and an Associate Professor of Genetics at Harvard Medical School. His laboratory studies how complex macromolecular networks are organized and how perturbations in those networks can lead to diseases such as cancer.

Albertha (Marian) Walhout obtained a PhD in Medicine at the University of Utrecht, the Netherlands, with a focus on Molecular Biology and Biochemistry. In 1998 she came to the USA for a post-doc at Harvard Medical School in Functional Genomics and Systems Biology. She started her lab at UMass Medical School in the spring of 2003. Her work centers on the elucidation of gene regulatory networks and how they relate to development, physiology and disease.

Hans V. Westerhoff is AstraZeneca Professor of Systems Biology at the Manchester Centre for Integrative Systems Biology (heading the Doctoral Training Centre Systems Biology), Professor of Microbial Physiology at the Free University Amsterdam and of Mathematical Biochemistry at the University of Amsterdam. Chairing the Steering Committee of the German HepatoSys program, he has worked on Hierarchical Control and Regulation, the siliconcell, EGF signalling, and DNA structure, exemplifying bottom-up Systems Biology.

Jun Wang is Director of BGI (previously known as the Beijing Genomics Institute) and was instrumental in founding the BGI Bioinformatics Department in 1999. Dr. Wang also holds a position as an Ole Rømer professor at the University of Copenhagen. He has authored 200+ peer-reviewed original papers and his research focuses on genomics and related bioinformatics analysis of complex diseases and agricultural crops, with the goal of developing applications using the genomic information.

Lothar Willmitzer is Director of the Max Planck Institute of Molecular Plant Physiology. His research interests focus around the small molecules/metabolites present in plant cells. More specifically his group is interested in the biosynthesis, transport and storage of such molecules an in the genes that control these processes.

John Yates is a Professor in the Department of Cell biology at The Scripps Research Institute. His research interests include development of integrated methods for tandem mass spectrometry analysis of protein mixtures, bioinformatics using mass spectrometry data, and proteomics. He is the lead inventor of the SEQUEST software for correlating tandem mass spectrometry data to sequences in the database.

Lingchong You is Paul Ruffin Scarborough Associate Professor of Engineering in the Pratt School of Engineering at Duke University. His laboratory explores design principles of biological networks and uses synthetic gene circuits for applications in computation, engineering and medicine.

Marino Zerial is Managing Director of the MPI-CBG in Dresden. He has been conducting interdisciplinary research on endocytosis and signalling, combining biochemistry, live cell imaging, image processing, functional genomics and computational approaches to systems analysis.