Cover: This month's cover highlights the Article "Automated analysis of high-content microscopy data with deep learning" by Oren Z Kraus, Ben T Grys, Charles Boone, Brenda J Andrews and colleagues. Here, deep learning is used to classify protein subcellular localization in genome-wide microscopy screens of GFP-tagged yeast strains. The resulting classifier (DeepLoc) outperforms previous classification methods and is transferable to new and highly divergent image sets. (Artistic rendition by Uta Mackensen).