Cover: This month’s cover highlights the Article “Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer” by Mary Lee, George T Chen, Marian L Waterman, John Lowengrub and colleagues, also highlighted by Dai and Locasale. Immunohistochemistry and mathematical modeling reveal a spotted pattern of metabolism and Wnt signaling in xenograft tumors of colon cancer cells, indicating a synergism between glycolysis and Wnt signaling that could be exploited for anti-tumor therapies. Scientific images by George Chen and Kehui Wang, Matlab simulations by Eric Puttock and Mary Lee. Cover design by George Chen.