Cover: This month’s cover highlights the Research Article “Parallel reverse genetic screening in mutant human cells using transcriptomics” by Bianca V Gapp, Tomasz Konopka, Sebastian MB Nijman and colleagues. The authors apply shallow transcriptomic profiling to uncover genotype-phenotype connections in 64 knockout cell lines across 10 stimuli. This study provides proof of concept for transcriptome-based reverse genetic screens in human cells. Cover concept by Bianca V Gapp, Tomasz Konopka, Vineet Dalal, and Sebastian Nijman, Ludwig Cancer Research. Cover design by Thomas Splettstößer (www.scistyle.com).