Cover: This month’s cover highlights the Research Article “Chemogenomics and orthology-based design of antibiotic combination therapies” by Sriram Chandrasekaran, James J. Collins, Murat Cokol and colleagues. The authors have developed a computer model that accurately predicts how antibiotics prescribed in combinations will inhibit bacterial growth. They leverage genomics and drug-interaction data in the model organism – E. coli, to facilitate the discovery of effective combination therapies in less-studied pathogens, such as M. tuberculosis. Cover concept by Sriram Chandrasekaran, Harvard University. Artistic rendition by Uta Mackensen.