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Author Guidelines

Revisions to these Guidelines

 

About Molecular Systems Biology

Editorial Policies

Manuscript Preparation

Submission

For Acceptance and Publication

Help and Contact

 

About the Journal

Aims and Scope

Systems biology is an integrative discipline that seeks to explain the properties and behaviour of complex biological systems in terms of their components and their interactions.

Molecular Systems Biology is a peer-reviewed author-pays online journal that publishes high-quality research in the fields of systems biology, synthetic biology and systems medicine. The Editors select manuscripts based on their novelty and wide biological significance. Although the primary emphasis of the journal is on molecular components and their interactions, systems studies at the organ level may also be considered. Works describing large-scale datasets will be judged, in part, by the extent to which these datasets are integrated both with each other and with computational models, with the ultimate aim to better understand the dynamic and complex nature of living systems. Reports of new experimental methods will also be considered in the context of this policy.

Topics falling within the scope of the journal include, but are not limited to: integrative genome-scale biology, quantitative biology, computational biology, metabolic and regulatory networks, evolution of genomes and biological networks, clinical and translational systems biology, synthetic biology and genome-scale biological engineering.

Molecular Systems Biology publishes research articles as full-length Articles or short Reports. The journal publishes also Reviews, Perspectives, News & Views, Correspondences and Editorials.

Bibliometrics

Impact Factor (2013): 14.1 (Thomson Reuters)

5-year Impact Factor (2013): 12.3 (Thomson Reuters)

Immediacy Index (2013): 2.4 (Thomson Reuters)

SJR (2013): 9.8 (JournalM3trics)

SNIP (2013): 2.9 (JournalM3trics)

h4 (2009-2013): 71 (Google Scholar)

Editorial Policies

Submission of a manuscript implies that it reports unpublished work and that neither itself, nor parts of it, have been published or are under consideration for publication elsewhere. By submitting a manuscript to Molecular Systems Biology, the authors guarantee that they have the appropriate authority from their employers and/or funding agencies to publish the work. Any related work under consideration, review, revision or accepted for publication elsewhere must accompany the submission if they are relevant to its scientific assessment.

Authorship Guidelines

Submission of a paper implies that all authors have seen and approved the manuscript and its contents, and that they are aware of the responsibilities connected to authorship. Signatures from all the authors are not required; it is the corresponding author’s responsibility to obtain agreement from all authors supporting the submission. All authors will be notified upon receipt of a new manuscript and upon acceptance of a manuscript, but the editorial office corresponds only with the Corresponding Author, whose responsibility it is to communicate with all other authors.

The nature of every author’s contribution must be specified both in the manuscript submission system and in the manuscript under the heading ’Author Contributions’.

Our authorship policies conform to international standards (see, for example, http://www.icmje.org/ethical_1author.html).

Use of living organisms

For Research Articles submitted to Molecular Systems Biology reporting experiments on live vertebrates and/or higher invertebrates, the corresponding author must confirm that all experiments were performed in accordance with relevant guidelines and regulations. The manuscript must include a statement in the Materials and Methods identifying the institutional and/or licensing committee approving the experiments, including any relevant details. For experiments involving human subjects, authors must identify the committee approving the experiments, and include with their submission a statement confirming that informed consent was obtained from all subjects.

Animal welfare

For studies reporting experiments on live vertebrates and/or higher invertebrates, the corresponding author must confirm that all experiments were performed in accordance with relevant guidelines and regulations. The manuscript must include a statement in the Materials and Methods identifying the institutional and/or licensing committee approving the experiments. The editors reserve the right to consult with board members or external experts and reject manuscripts that contain animal experiments that do not conform to NIH or MRC guidelines for animal welfare. For further information see: http://grants.nih.gov/grants/olaw/olaw.htm; http://www.mrc.ac.uk/Ourresearch/Ethicsresearchguidance/Useofanimals/index.htm.

We encourage authors to follow the ARRIVE guidelines (PLoS Biol. 8(6), e1000412, 2010) for reporting studies involving animals. Please see the following website for details: http://www.equator-network.org/reporting-guidelines/improving-bioscience-research-reporting-the-arrive-guidelines-for-reporting-animal-research/

Human Subjects

For experiments involving human subjects the corresponding author must identify the committee approving the experiments and include a statement that informed consent was obtained from all subjects and that the experiments conformed to the principles set out in the WMA Declaration of Helsinki and the Department of Health and Human Services Belmont Report. Editors or referees may request further documentation confirming that this is the case. 

Any restrictions on the availability or on the use of human data or samples should be clearly specified in the manuscript. Any restrictions that may detract from the overall impact of a study or undermine its reproducibility will be taken into account in the editorial decision. 

For clinical trials reporting, the authors should fill out a CONSORT flow diagram and submit it as supplementary information. We also encourage authors to follow the CONSORT reporting guidelines http://www.consort-statement.org. Please see the EQUATOR website for details. Clinical trials should also be registered as recommended by the International Committee of Medical Journal Editors, and the trial registration number should be provided.

Reporting Guidelines

Authors are encouraged to follow the EQUATOR Network reporting guidelines for the following:

Type of Study Guidelines
Animal research ARRIVE
Parallel group randomized trials CONSORT
Conensus-based Clinical Case Reporting CARE
Prognostic marker studies REMARK
Diagnostic Accuracy STARD
Meta-analysis of observational studies MOOSE
Systematic reviews and meta-analysis PRISMA
Observational studies STROBE
Genetic association studies STREGA
Statistical analyses and methods STAMPL
Microarray/deep sequencing studies MIAME
Studies using biospecimens BRISQ

Biosecurity

Planned research and results from experiments should be evaluated at an early stage for possible dual use concerns. In such cases, authors should first consult with an appropriate local body concerning the implications for biosecurity and public health. For further information see the U.S. National Science Advisory Board for Biosecurity's recommendations and the U.S. National Select Agent Registry.

Authors should explicitly describe any potential biosecurity implications and the local body’s assessment in their cover letter at submission. The threat posed by the potential abuse of certain experimental data or material for bioweapons, terrorist or other criminal activities may require that editors balance the risks and benefits of publication. The ultimate decision whether to publish the paper as submitted or with suggested changes is the prerogative of the editors after consultation with board members or external experts in biosafety, biosecurity, or public and environmental health.

Availability of published material, data and software

It is understood that by publishing their work in Molecular Systems Biology, authors agree to the disclosure of their findings and the release of their data, reagents and methods to enable colleagues in academic research to verify, reproduce and build on the published work. Materials must be made available at a reasonable cost that reflects production and distribution. The distribution of published materials does not automatically confer a right of co-authorship. The guidelines below were inspired, in part, by the recommendations formulated by the Board on Life Sciences from the National Academies Sharing Publication-Related Data and Materials: Responsibilities of Authorship in the Life Sciences (National Academies Press, 2003).

  • Organisms, viruses, cells, nucleic acids, antibodies, and other reagents that were used in the research reported and that are not available from commercial suppliers should be freely available to colleagues in academic research. Human patient samples and data should be made available in accordance with the relevant ethical standards.
  • Datasets obtained by experimentation, computation or data mining, should be made freely available, without restriction. This holds without exception to data that are central and integral to the findings reported in the paper and it is strongly recommended for any remaining associated data.
  • Software should be described in sufficient detail to allow reproduction of the underlying algorithms by others. This may be achieved by providing the appropriate narrative or mathematical description, pseudocode and, possibly but not obligatorily, the source code. If a specific implementation is the focus of the study, it is strongly recommended that non-commercial users are granted free access to this implementation.
  • If a piece of software is central to the study, it is strongly recommended that it provides appropriate mechanisms (eg data import and export functionalities) for a reasonable integration in other workflows.
  • Any restrictions on the availability or on the use of included data, software and databases should be clearly specified in the paper. These restrictions may detract from the overall impact of a study, in particular when datasets, software or databases are central to the findings reported, and, therefore, will be taken into account in the final editorial decision.

Molecular Systems Biology will only review and publish manuscripts if the authors agree to make all data that cannot be published in the journal itself (e.g. novel nucleotide sequences, structural data, or data from large-scale gene expression experiments) freely available, where possible, in an appropriate public database (detailed guidelines can be found below).

Conflicts of interest

In the interests of transparency and to help editors and reviewers assess any potential bias, Molecular Systems Biology requires authors of original research papers to declare any competing commercial interests in relation to the submitted work. It is difficult to specify a threshold at which a financial interest becomes significant, but as a practical guideline, we would suggest this to be any undeclared interest that could embarrass you were it to become publicly known. Referees and editors are also subject to Conflict of Interest regulations.

Scientific Integrity

The editorial staff of Molecular Systems Biology is strongly committed to maintaining high standards of integrity of the published scientific record. The journal requests that authors take note of and adhere to guidelines established by the U.S. Department of Health and Human Services Office of Research Integrity (http://ori.dhhs.gov). The journal will investigate suspected instances of scientific fraud, inappropriate image manipulation, plagiarism, duplicate publication and other cases that violate research ethics. Depending on the outcome of these investigations, the journal may opt to publish errata or corrigenda, or, in cases of serious scientific misconduct, either to ask authors to retract their paper, or to impose retraction on them. In such cases, the authors’ employers may also be contacted. As a matter of policy, the journal will collaborate with independent institutional investigations into misconduct and usually accept the outcome of such investigations.

An erratum is notification of an important error made by the journal, whereas a corrigendum is notification of an important error made by the author(s).

Refutations of articles published in Molecular Systems Biology can be considered for the Correspondence section of the journal. Such correspondence will almost always include data to support the arguments of the correspondent. The original authors of that article will be offered the opportunity to respond side-by-side with the correspondence. Both pieces will be peer reviewed at the discretion of the editor and acceptance depends on the strength of the arguments raised as well as the importance of the matter to a general readership. Publication of the correspondence does not automatically entail publication of a response of the authors of the challenged research paper. After one round of correspondence, Molecular Systems Biology will consider the matter closed and will not publish further exchanges.

Molecular Systems Biology is a member of the Committee on Publication Ethics (COPE).

Data collection and presentation

Presented data must represent the findings in a fair and accurate manner. This includes appropriate statistical analysis and image processing. For further details, please refer to these guidelines.

The Editors reserve the right to request original versions of figures and the source data that were used to assemble the figure from the authors of a paper under consideration, or of a paper already published in Molecular Systems Biology.

Originality and Plagiarism

The editors require that any information published in the journal represents a substantially novel contribution to the scientific record. Any manuscript submitted to Molecular Systems Biology should therefore not contain content that has been formally published in a peer reviewed journal or another formally citable manner, whether in print or electronic. This includes websites, blogs and the news media.

Subject to licensing restrictions, Molecular Systems Biology will consider for publication manuscripts based on information that has been previously discussed by the authors at scientific conferences in the form of posters, talks, abstract books, meeting reports or webcasts. Manuscripts may be posted prior to or at the time of submission on recognised non-peer reviewed pre-publication platforms dedicated to discussion among peers, including the preprint servers bioRXiv and arXiv, and Faculty1000 posters. The details of the preprint server concerned and any accession numbers must be included in the cover letter accompanying submission of the manuscript. Molecular Systems Biology will also consider manuscripts based on unpublished academic theses released in accordance with institutional rules.
 
Any text, data, material, images, ideas or quotes should be attributed to the original source, even if it is by the same authors. If necessary, authors should seek permission to use the material from the copyright holder in accordance to licensing stipulations. Molecular Systems Biology's policies on attribution follow the standards set by the Associated Press. It is at the discretion of the editors whether prior publication of such related material prevents subsequent publication in the journal.
 
Plagiarism includes both the theft or misappropriation of intellectual property and the substantial unattributed textual copying of another's work. Molecular Systems Biology uses CrossCheck, a multi-publisher initiative to screen submitted content for plagiarism, to detect overlapping and similar text (including self-plagiarism) prior to publication. To find out more about CrossCheck visit http://www.crossref.org/crosscheck.html.

Embargo Policy

The content of papers and any associated press releases is strictly embargoed until the official date of publication of a manuscript. Accepted contributions can be discussed with the media from one week before the publication date provided the journalist respects the embargo date. We will press release selected papers with summaries. Authors may arrange their own publicity, but must adhere to the embargo conditions. Further details can be provided by the editorial office (msb@embo.org).

Citation

Comprehensive and accurate citation of the relevant literature is essential. We require citation of the primary literature wherever appropriate. To enable this, we have removed any limits on the total number of references in the bibliography, and the reference list is no longer subject to manuscript length format requirements (for details, see below).

Editorial Process

All submissions are initially assessed by an Editor of the journal, and may also be seen by a Senior Editor or a member of the Advisory Editorial Board. Manuscripts judged by the editors to be of potential interest to our readers are sent out for formal peer review. The decision concerning publication, revision or rejection is taken by the Editor based on the reviewers' reports and recommendations. Papers may, however, be returned to authors without review if in the judgement of the Editors, they fall out of scope of the Journal, fail to meet the criteria of wide biological significance and novelty, or if they are considered too preliminary.

Molecular Systems Biology makes the editorial process transparent for all accepted research manuscripts, by publishing as an online supplementary document (the Peer Review Process File) all correspondence between authors and the editorial office relevant to the decision process. This will include all referee comments directed to the authors, as well as the authors’ point-by-point responses. Internal communications and informal consultations between editors, editorial advisors or referees will remain excluded from these documents.

Importantly, referee anonymity will be strictly maintained.

Authors have the possibility to opt out of the transparent process at any stage prior to publication.

To further facilitate transparency, Molecular Systems Biology has removed the “Confidential Comments” field from our referee reporting forms. This is to ensure that the authors receive all information pertinent to the decision made on a manuscript. Referees should be aware that all comments will be transmitted to the authors and the other referees. Should there be any issues with the manuscript, in particular concerns about ethical standards, data integrity, biosecurity, or conflicts of an academic or commercial nature that need to be communicated directly and confidentially to the editor, this can be done by email (msb@embo.org).

Please see the following editorial for more information on these policies: From bench to website

Transfer policies

Molecular Systems Biology is editorially independent of the other EMBO Scientific Publications.

Authors can choose to transfer manuscripts rejected from Molecular Systems Biology to any of the other three EMBO Publications (EMBO Journal, EMBO reports, EMBO Molecular Medicine) by following the instructions appended to the editorial decision letter. Manuscripts transferred post-review will automatically include the referees’ reports and identities, and the editors will aim to use these reports in arriving at a rapid decision. Editors may choose to seek additional advice from referees or editorial advisory board members in cases where this would enhance informed decision-making.

Manuscript Preparation

General Guidelines for Submission

The Editors reserve the right to return manuscripts that are not in accordance with the following instructions. However, manuscript will not be rejected out of hand for format reasons: while published manuscripts are expected to conform tightly to the following guidelines, this is not a requirement at first submission.

Manuscripts must be written in clear and concise English and be intelligible to a broad readership. Prior to submission, authors may benefit from having their manuscript reviewed for clarity by colleagues and/or by using one of the many English language-editing services that are available.

Original Research Articles

Molecular Systems Biology publishes original research in two main formats: Articles and Reports.

Articles

Articles are full-length original research papers and should be divided into the following sections:

  • Title page
  • Abstract
  • Introduction
  • Results
  • Discussion
  • Materials and methods
  • Acknowledgements
  • Author Contributions
  • Conflict of Interest
  • References
  • Figure legends
  • Figures
  • Tables
  • Expanded View (replacing Supplementary Information)

The total character count (including spaces) for an Article, excluding the Methods section, tables, Expanded View material and references, but including title page, abstract, and figure legends should not exceed 60,000 characters (the exact character count to be stated on the title page). Articles typically have 6-8 Figures.

Reports

Reports are short publications focusing on a particularly provocative and novel aspect of a study. They should have an Abstract phrased in terms that are comprehensible to readers outside the discipline. Results and Discussion sections can be combined. The remaining sections are organized as described above for Articles.

The total character count (including spaces) for Reports, excluding the Methods section, tables and Expanded View material, but including title page, abstract, figure legends and references should not exceed 22,000 characters (the exact character count to be stated on the title page). Reports have, in principle, a maximum of 3 Figures.

Title Page

The title should be short and informative, and should not contain any abbreviations (for example, Epithelial-Mesenchymal Transition should not be abbreviated to EMT). However, commonly used gene or protein acronyms are acceptable. The total length of the title should not exceed 100 characters (including spaces). Serial titles are not accepted.

The full name of each author should be given. Multiple first-authorships are acceptable and should be indicated. Numbers in superscript should be used to indicate the department, institution, city with postal code and country, for each author. Any changes of address may also be given in numbered footnotes. It is possible to name more than one author as the correspondent of a published article, although we will by default address all correspondence to the single author listed as Corresponding Author upon submission.

Please provide a running title of no more than 50 characters including spaces.

Up to five keywords, which may or may not appear in the title, should be given in alphabetical order, below the abstract, each separated by a slash (/).

Subject Categories are used to structure the current and archived online content of Molecular Systems Biology, and to help readers interested in particular areas of molecular biology find relevant information more easily. Authors should suggest appropriate Subject Categories for the submitted manuscript. One or two categories may be selected from the following list:

 

Systems & Synthetic Biology categories
Quantitative Biology & Dynamical Systems Genome-Scale & Integrative Biology
Network Biology Synthetic Biology & Biotechnology
Systems Medicine Computational Biology
Methods & Resources  

 

Molecular & Cell Biology categories
Ageing Metabolism
Cancer
Microbiology, Virology & Host Pathogen Interaction
Cell Adhesion, Polarity & Cytoskeleton Molecular Biology of Disease
Cell Cycle Neuroscience
Cell Death & Autophagy Pharmacology & Drug Discovery
Chemical Biology Plant Biology
Chromatin, Epigenetics, Genomics & Functional Genomics Post-translational Modifications, Proteolysis & Proteomics
Development & Differentiation Protein Biosynthesis & Quality Control
DNA Replication, Repair & Recombination RNA Biology
Evolution Signal Transduction
Genetics, Gene Therapy & Genetic Disease Stem Cells
Immunology Structural Biology
Membrane & Intracellular Transport Transcription

 

Abstract

This should be a single paragraph not exceeding 175 words. The Abstract should be comprehensible to readers before they have read the paper, and abbreviations should be avoided where possible (as for the title). Reference citations within the abstract are not permitted. The abstract should describe all key novel findings of the study.

Introduction

The Introduction should be succinct and without subheadings. It should provide only the necessary background information, rather than comprise a comprehensive review of the field. Citation of the primary literature is required where appropriate (see section on Citations).

Results

The Results section, and associated figures, tables and Expanded View information, must accurately describe the findings of the study. Figure order should follow the text. Detailed methodological descriptions should be restricted to the Materials and Methods section. ‘Data not shown’ is not permitted (see below): all significant data should be displayed in the main figures or Expanded View information.

Discussion

The Discussion should accurately interpret the results, but not be repetitive with the Results section. Authors are encouraged to discuss their work in the broader context. Related published data must be appropriately discussed and cited. Speculation is allowed but should be clearly labelled as such.

Materials and methods

This section should contain sufficient detail so that all experimental procedures can be repeated by others, in conjunction with cited references. Reagents must be described in such a way as to allow readers to identify them unequivocally and/or reproduce them. For example, antibodies epitopes should be described and siRNA and other probe sequences must be provided. In cases where detailed methods cannot be described within the length limits of the article, additional Materials and Methods can be included as Expanded View information. This additional information should, however, not be of immediate importance for the understanding of the manuscript, and it is not permissible to move the entire “Materials and methods” section into the Expanded View.

Acknowledgements

These should be placed at the end of the text and not in footnotes. Personal acknowledgements should precede those of institutions or agencies. Grant numbers are permissible. Dedications are discouraged.

Author Contribution

Molecular Systems Biology requires a statement specifying the contributions of every author. Further details on authorship can be found here.

Conflict of Interest

Molecular Systems Biology requires a statement specifying whether or not the authors have a Conflict of Interest (see above for details). In the case of a Conflict of Interest, this must be specified.

References

As a matter of policy, Molecular Systems Biology requires the citation of primary literature (over review articles) wherever appropriate. Authors are responsible for the accuracy of the references. Authors are responsible for ensuring that the related literature is accurately and comprehensively discussed and cited. Review articles should only be cited for general background information, the proposal of certain concepts or similar purposes, whereas primary research articles should preferentially be referenced to introduce the question being addressed or to support the conclusions and interpretations of the results. Articles in press can be cited with the explicit permission corresponding author of the study; the journal name has to be included and, where available, the Digital Object Identifier. Reference formatting information can be found here.

Figure Legends

Figure legends should contain sufficient information to allow the reader to follow the data presented without referring back to the text, but should not be redundant with the Results section. Each figure must contain a heading, and each panel a subheading. All symbols and abbreviations used in the figure must be defined, unless they are common abbreviations or have already been defined in the text. Experimental details should, where possible, be given in the Materials and Methods section, and not repeated in the figure legends. Figure legends should be formatted such that each panel, or group of panels, has its own entry with the panel letter (or range) on the left and the description on the right. The description of specific panels can be preceded or followed by free text describing features, statistics or values pertinent to all panels. For example:

Figure 1 - Generation of hiPSCs from a patient with type-2 long-QT syndrome.

    A  Genetic screening in the patient revealed the heterozygous single-nucleotide mutation Aright arrowT in exon 13 of the KCNH2 gene, in position 2987 of the coding sequence (CDS) (c.A2987T, NM_000238.3), resulting in the substitution of an asparagine with an isoleucine at position 996 of the protein (N996I, NP_000229.1).
    B  The N996I mutation (red dot) is located in the C-terminal of the HERG protein, which is made of six trans-membrane domains (S1-S6), an amino (NH2) domain, a carboxyl (COOH) domain, and a pore (P) region.
    C  Example of a hiPSC colony harbouring the c.A2987T (N996I) KCNH2 mutation (LQT2-hiPSCsN996I). Scale bar: 400 mu;m.

 

Expanded View (replaces Supplementary Information)

[Note: authors do NOT need to reformat their manuscript at first submission. The guidelines below are to be followed when submitting a revision.]

All data and information that are essential to support the scientific arguments made in the paper should be presented in figures that will be included in the main paper. Figures, tables or text sections that are not required by the general reader to understand the principle findings of the paper and that would disrupt the flow of paper should be submitted as 'Expanded View', which will be displayed in collapsible form and will replace Supplementary Information. Please refer to each Expanded View item in the body of the text or the figure legends.

Expanded View Figures, tables or text represent an integral part of the published paper and benefit from the same peer-review and editorial production process as the other sections of the paper. Please note the Expanded View items are restricted to information essential to support the scientific arguments made in the paper. Peripheral, tangential or further reaching data and information should not be presented. Reference to 'data not shown' is discouraged'.

Expanded View items (Figures, Tables, Text) are displayed inline in the HTML version of the paper and are individually expandable/collapsible [note: currently files are linked to for download but full HTML rendering will come in the near future].

The article should be self-explanatory without the Expanded View sections. The scope of Expanded View sections should therefore be limited to the following categories:

  • controls and results from technical optimization experiments
  • replication or confirmation of previous results
  • negative results
  • extended methods and detailed protocols
  • mathematical demonstrations, algorithms, computer code and models
  • datasets

Note that controls and replicates to directly support the data presented in a figure should be supplied as 'Source Data' file linked to the relevant figure.

All Expanded View items should be cited in the text as "Figure E1", "Figure E2", Table E1", "Table E2", etc..., throughout the text.

Every Expanded View item should be accompanied by a legend that explains the content of the item. Expanded View legends should simply be included in the main manuscript file after the legends to the Figures and use the conventional format:

  • "Figure E1. Title of the item. Explanatory legend."

Each Expanded View item should in principle be supplied as an individual file. If this is not possible due to the nature of the information provided in Expanded View and the way it needs to be presented, a single PDF file (including a Table of Contents) can also be provided in exceptional cases and in agreement with the editors.

The following formats are accepted:

  • Expanded View Figure: jpg, gif, tiff, eps, pdf
  • Expanded View Tables (less than 50 rows): Word, Excel
  • Expanded View Text: Word, LaTeX
  • Expanded View Datasets and large tables (more than 50 rows): Excel, tab-delimited text, comma-separated values (csv), XML
  • Expanded View Code and Models: plain text, XML, ZIP compressed archives (including a README text file at the top level to detail the content and nature of each file included in the archive)
  • Expanded View Movie: mpeg, mov, avi

For the PDF version of the article, all displayable Expanded View items (Figures, Text and small tables) are automatically converted into PDF format and appended to the end of the article as part of a single downloadable 'PDF+' file. Files marked 'PDF' display the paper without Expandable View Items.

Unpublished Data

Molecular Systems Biology does not permit citation of “Data not shown.” All data referred to in the paper should be displayed in the main or Expanded View figures. “Unpublished observations” may be referred to in exceptional cases, where these are data peripheral to the major message of the paper and are intended to form part of a future or separate study. Personal communications (Author name(s), personal communications) must be authorised in writing by those involved, and the authorisation sent to the editorial office at time of submission. Care should be taken that embargo policies are not contravened. References to manuscripts in preparation or submitted, but not yet accepted, should be cited in the text as (Author names(s), in preparation), and should not be included in the list of references. Copies of such manuscripts should be enclosed at submission for reviewing purposes where relevant, as should manuscripts in press, which should be cited in the reference list (see below)

Conventions and Abbreviations

In general, the journal follows conventions given in Scientific Style and Format: The CBE Manual for Authors, Editors and Publishers (1994) Cambridge University Press, Cambridge, UK, 6th edn. Please follow Chemical Abstracts and its indexes for chemical names. For guidance in the use of biochemical terminology follow the recommendations issued by the IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. In general, genes and genotypes should be indicated in italics; proteins and phenotypes should not be italicized.

Authors should use approved gene and gene product nomenclature and apply the italicization and capitalization formatting as appropriate for each organism’s standard nomenclature. Please consult the appropriate nomenclature databases for correct gene names and symbols. Some useful general resources are: Entrez Gene (http://www.ncbi.nlm.nih.gov/gene); UniProt (http://www.uniprot.org/).

Try to restrict the use of abbreviations to SI symbols (standard units of measurements) and those recommended by the International Union of Pure and Applied Chemistry (IUPAC). Abbreviations should be defined in brackets after their first mention in the text, not in a list of abbreviations. SI symbols and symbols of chemical elements may be used without definition in the body of the paper. Abbreviations of standard biochemical compounds, e.g. ATP, DNA, nucleotides in nucleic acids, and amino acids in proteins, need not be defined. Common language abbreviations, such as e.g. or i.e., should not be used.

Other article types

Reviews

Review articles aim to provide accessible, authoritative overviews of a field or topic. Reviews should communicate a sense of enthusiasm, weaving background information with the latest advances, and placing both of these elements in the context of the rest of the field. The readership of Molecular Systems Biology encompasses a wide range – from advanced undergraduate and graduate students to group leaders and professors. Technical terms and specialist jargon should be avoided or clearly defined.

Reviews are usually commissioned but can also be submitted. After submission, all articles are refereed.

The main text should be about 5,000 words. References should be limited to ~100 for a long Review concentrating on significant original research papers.

Perspectives

Perspective papers provide a platform to expose hypotheses and concepts that open up new avenues in Systems and Synthetic Biology. A Perspective paper has a more focused scope than a Review in the sense that it may highlight the work of a single laboratory and may present a particular viewpoint on a field.

This format can also accommodate proposals, in which existing knowledge is used to delineate the plan of an ambitious project that would provide decisive and novel insight in the fields of Systems and Synthetic Biology. The proposed goal has to be highly original and of broad interest to the community. A proposal should detail the various aspects of the project such as its objectives, main concrete steps and milestones, utility and implications while in development and after completion.

Perspectives are usually commissioned but can also be submitted. After submission, all articles are refereed.

The main text should be about 5,000 words. References should be limited to ~100.

News & Views

Molecular Systems Biology’s News & Views section provides a forum in which scientific news can be communicated to a wide audience spanning the varied disciplines covered in systems biology. News & Views articles are short (usually 800-900 words), and have as much in common with journalistic news reports as the formal scientific literature. They should therefore make clear the news and opinions being discussed, and communicate a sense of excitement, yet provide a critical evaluation of the research or approach concerned.

Correspondence

A Correspondence is a flexible format that may include anything of interest to the journal’s readers, from policy debates to announcements to ‘matters arising’ from research papers. A Correspondence may describe primary research data, but only one Figure and one Table are allowed. A Correspondence has no abstract and should be limited to 1000 words in principle. The number of references should not exceed 10 for either the Correspondence or its Reply. Expanded View information can in principle only be in the form of structured data or dataset files.

Authors must submit a competing financial interests statement, which is printed only if they declare that they have competing interests. In cases where a Correspondence is critical of a previous research paper, the authors are normally given the option of publishing a brief reply. Criticism of opinions or other secondary matter does not involve an automatic right of reply.

Refutations and commentaries on previously published articles are always peer reviewed. Other types of Correspondence may be peer reviewed at the editors' discretion.

General Formatting Guidelines

Text

The Editorial Office will only accept text files in LaTeX (download template files), RTF, or MS Word format. The final character count must be clearly indicated on the title page of the manuscript. Manuscripts that do not comply with the formatting guidelines, or exceed the length restrictions, may be returned to the authors for amendment.

Please submit the full text (including figure legends, tables, and references) as a single MS Word or RTF file.

Figures

Figures and Expanded View figures should be presented in the order they are mentioned in the text.

Figures should be labelled in consecutive Arabic numerals. The final size of figures will be between 82 mm and 172 mm wide on the printed page. Please bear this in mind when submitting your manuscript for review and allow for sufficient resolution at a suitable size.

Figures divided into parts should be labelled with an upper-case, bold letter (Helvetica Font). Figures with several parts should also be in proportion, with consistently sized lettering so that the whole figure can be reduced by the same amount to the smallest size at which the essential details are visible. Use Courier font for sequence data and Symbol font for any symbols.

All lettering should be done using standard fonts (Helvetica, Times, Symbol, Courier) and retained in a separate layer (if possible) so that the production team can adapt any labels to the Journal’s style if necessary. All fonts used for labelling the figures should also be embedded in the final files if the software package offers this option.

Scale bars, rather than magnification factors, should be used, with the length of the bar defined in the legend rather than on the bar itself. In general, visual cues on the figure itself are preferred rather than verbal explanations (for example, ‘broken line’ or ‘filled black triangles’) in the legend.

When preparing figures of microscopy images, please note that we strongly encourage the use of colours that are suitable for colour-blind readers: for example, the use of magenta/green is preferred over red/green for 2-channel images.

For publication, we use TIFF and EPS files in PC or Macintosh format, preferably from Photoshop or Illustrator software. We cannot accept Freehand, Canvas, CorelDRAW or MacDrawPro files. These files must be converted to postscript (eps) format. For any figures submitted in photoshop or tiff format we require layered files to be sent whereby all text, arrows or additional attributes are placed on individual layers within the file. For line art/charts/graphs we prefer to work with Adobe Illustrator AI or EPS files. We can also accept high-resolution PDF files.

Non-vector graphics should be preserved at high resolution: 300 dpi minimum at final size for greyscale or colour halftone images, and 1,000 dpi minimum for bitmap (b/w) artwork.

Further information regarding the preparation of electronic figures is available in this document [PDF].

Molecular Systems Biology does not have colour charges for figures, and the authors are therefore welcome to submit full colour figures.

Data presentation

Figures must accurately reflect the results of the experiments. Appropriate controls, markers and scale bars should be included in all panels. Statistical tests must be clearly defined and appropriate to the data.

Source data for figures
Molecular Systems Biology strongly encourages authors to upload the ‘source data’–for example, tables of individual numerical values and measurements–that were used to generate figures. These files are separate from the Expanded View information files and are submitted using the "figure source data" option in the tracking system. Source data are directly linked to specific figure panels so that interested readers can directly download the associated ‘source data’ (see, for example, <http://tinyurl.com/365zpej>), for the purpose of alternative visualization, re-analysis or integration with other data.

The data should at usable by readers who understand the topic of the paper and should, at minimum, allow users to redraw the figures using an alternative graphical representation. Data should be annotated to provide essential information values included, providing a clear link to the figure legends in the main paper.

Image Processing
Images submitted with a manuscript for review should be minimally processed (for instance, to add arrows to a micrograph). Authors should retain their unprocessed data and metadata files, as editors may request them to aid in manuscript evaluation. If unprocessed data are unavailable, manuscript evaluation may be stalled until the issue is resolved. All digitized images submitted with the final revision of the manuscript must be of high quality and have resolutions of at least 300 dpi for colour, 600 dpi for greyscale and 1,200 dpi for line art.

A certain degree of image processing is acceptable for publication (and for some experiments, fields and techniques is unavoidable), but the final image must correctly represent the original data and conform to community standards. The guidelines below will aid in accurate data presentation at the image processing level; authors must also take care to exercise prudence during data acquisition, where misrepresentation must equally be avoided. Where appropriate, manuscripts should include Methods as part of the Expanded View that describes for each figure the pertinent instrument settings, acquisition conditions and processing changes, as described in this guide.

Authors should list all image acquisition tools and image processing software packages used. Authors should document key image-gathering settings and processing manipulations in the Methods.

Images gathered at different times or from different locations should not be combined into a single image, unless it is stated that the resultant image is a product of time-averaged data or a time-lapse sequence. If juxtaposing images is essential, the borders should be clearly demarcated in the figure and described in the legend.

The use of touch-up tools, such as cloning and healing tools in Photoshop, or any feature that deliberately obscures manipulations, is to be avoided.

Processing (such as changing brightness and contrast) is appropriate only when it is applied equally across the entire image and is applied equally to controls. Contrast should not be adjusted so that data disappear. Excessive manipulations, such as processing to emphasize one region in the image at the expense of others (for example, through the use of a biased choice of threshold settings), is inappropriate, as is emphasizing experimental data relative to the control.

When submitting revised final figures upon conditional acceptance, authors may be asked to submit original, unprocessed images.

Electrophoretic gels and blots
Positive and negative controls, as well as molecular size markers, should be included on each gel and blot. For previously characterized antibodies, a citation must be provided. For antibodies less well characterized in the system under study, a detailed characterization that demonstrates not only the specificity of the antibody, but also the range of reactivity of the reagent in the assay, should be published as part of the Expanded View. The display of cropped gels and blots in the main paper is permitted if it improves the clarity and conciseness of the presentation. Cropped gels in the paper must retain all important bands, and space (several band-widths) should be retained above and below the relevant band(s). Vertically sliced images that juxtapose lanes that were non-adjacent in the gel must have a clear separation or a black line delineating the boundary between the gels. Quantitative comparisons between samples on different gels/blots are discouraged; if this is unavoidable, the figure legend must state that the samples derive from the same experiment and that gels/blots were processed in parallel. Loading controls must be run on the same blot. High-contrast gels and blots are discouraged, as overexposure may mask additional bands. Authors should strive for exposures with gray backgrounds. Multiple exposures should be presented in the Expanded View if high contrast is unavoidable. Immunoblots should be surrounded by a black line to indicate the borders of the blot, if the background is faint. For quantitative comparisons, appropriate reagents, controls and imaging methods with linear signal ranges should be used.

Microscopy
Authors should be prepared to supply the editors with original data on request, at the resolution collected, from which their images were generated. Cells from multiple fields should not be juxtaposed in a single field; instead multiple supporting fields of cells should be shown in the Expanded View. Specific guidelines: Adjustments should be applied to the entire image. Threshold manipulation, expansion or contraction of signal ranges and the altering of high signals should be avoided. If ‘Pseudo-colouring’ and nonlinear adjustment (for example ‘gamma changes’) are used, this must be disclosed. Adjustments of individual colour channels are sometimes necessary on ‘merged’ images, but this should be noted in the figure legend. We encourage inclusion of the following with the final revised version of the manuscript for publication: In the Methods, specify the type of equipment (microscopes/objective lenses, cameras, detectors, filter model and batch number) and acquisition software used. Although we appreciate that there is some variation between instruments, equipment settings for critical measurements should also be listed. Further Methods included as part of the Expanded View (or part of a larger Methods section) titled ‘equipment and settings’ should list for each image: acquisition information, including time and space resolution data (xyzt and pixel dimensions); image bit depth; experimental conditions such as temperature and imaging medium; and fluorochromes (excitation and emission wavelengths or ranges, filters, dichroic beamsplitters, if any). The display lookup table (LUT) and the quantitative map between the LUT and the bitmap should be provided, especially when rainbow pseudocolor is used. If the LUT is linear and covers the full range of the data, that should be stated. Processing software should be named and manipulations indicated (such as type of deconvolution, three-dimensional reconstructions, surface and volume rendering, ‘gamma changes’, filtering, thresholding and projection). Authors should state the measured resolution at which an image was acquired and any downstream processing or averaging that enhances the resolution of the image.

Statistical analysis
All statistical analyses performed in the work must be clearly described, including the name of the test performed and the number (n) of independent experiments underlying each analysis. Authors must justify the use of a particular test and explain whether their data conform to the assumptions of the tests. In particular:

  • When using statistical methods based on the normal distribution authors should explain how they tested their data for normality. If the data do not meet the assumptions of the test, then a non-parametric alternative should be used.
  • When making multiple statistical comparisons on a single data set, authors should explain how they adjusted the alpha level to avoid an inflated Type I error rate, or they should select statistical tests appropriate for multiple groups.
  • For each experiment, the number of both technical and biological replicates should be clearly stated. Biological replicates are derived from independent experiments using separately obtained biological samples, while technical replicates are created by repeated measurements on the same biological sample. In general, technical replicates should be averaged before any statistical inference tests are performed.
  • In cases where n is small, appropriate statistical tests should be employed and justified in the text.

Graphs must include clearly labelled error bars for cases where more than two independent experiments have been performed (error bars should not be shown for technical replicates). For more information on the appropriate use of standard deviation, standard error, and confidence intervals please refer to Cumming et al (2007). When n is small (n < 5), we recommend that the individual data from each experiment be plotted alongside an error bar. Figure legends should contain a basic description of n, P, and any relevant statistical tests or error bars.

Tables

Tables should be typed on separate sheets and numbered consecutively with Roman numerals (I, II, III, IV). Tables should be self-explanatory and include a brief descriptive title. Footnotes to tables indicated by lower-case superscript letters are acceptable, but they should not include extensive experimental detail.

References

Only articles that have been published or that are accepted for publication at a named publication should be cited in the reference list. In the text of the manuscript, a reference should be cited by author and year of publication; no more than two authors may be cited per reference; ‘et al’ should be used if there are more than two authors (i.e. Smith & Jones, 2003; Smith et al, 2000). Papers accepted for publication must be cited with the corresponding author&7rsquo;s permission and should include title and all author names (or initials if any of the authors are co-authors of the present contribution), as well as either the DOI, if available, or the term ‘in press’. In the reference list, citations should be listed in alphabetical order and then chronologically, with the authors’ surnames and initials inverted; where there are more than 20 authors on a paper, the first 20 will be listed, followed by ‘et al.’. Publications by the same author(s) in the same year should be identified with a, b, c after the year of publication. The name of each journal should be abbreviated according to Index Medicus and italicized. References should therefore be listed (and will subsequently appear in print) as follows:

Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, Koenig KL, Shore RE (2002) Aspirin and lung cancer in women. Br J Cancer 87: 49-53

Book chapters and books can be cited in the following way:

Price SR, Oubridge C, Varani G, Nagai K (1998) Preparation of RNA-protein complexes for X-ray crystallography and NMR. In RNA-Protein Interaction: Practical Approach, Smith C (ed) pp 37-74. Oxford: Oxford University Press

Sambrook J, Fritsch E & Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbour Press, Cold Spring Harbour, New York, USA

Links to online resources and websites should be cited in the text only, and should be available long-term (e.g. permalinks or DOI wherever possible). URLs should not appear in the reference list.

Data deposition

Large-scale datasets, sequences, atomic coordinates and computational models should be deposited in one of the relevant public databases prior to submission (provided private access is available at the database) and authors should include accession codes in the Materials & Methods section. The suggested wording for referring to accession identifiers in a manuscript is the following: “The [protein interaction | microarray | mass spectrometry ] data from this publication have been submitted to the [name of the database] database [URL] and assigned the identifier [accession | permalink | hashtag ].” If necessary, please include in the manuscript the relevant information (username and password) for confidential access by peer-reviewers.

Data for which no suitable public database exists should be included, if possible, as dataset files in the Expanded View. In cases where data can not be confidentially deposited in a public database, and is too large to be included in the Expanded View, please contact the editorial office for advice on how to make these data available for refereeing purposes.

Functional genomics data

Microarray and sequencing-based functional genomics data should be deposited in the ArrayExpress (http://www.ebi.ac.uk/arrayexpress/), GEO (http://www.ncbi.nlm.nih.gov/geo/) or CIBEX (http://cibex.nig.ac.jp/index.jsp) databases in compliance to the MIAME (http://www.mged.org/Workgroups/MIAME/miame.html) standards and the MINSEQE (http://www.mged.org/minseqe/) draft proposal.

Proteomics and molecular interactions

Mass spectrometry datasets should be deposited in a machine-readable format (e.g. mzML if possible) in one of the major public database, for example Pride (http://www.ebi.ac.uk/pride/) or PeptideAtlas(http://www.peptideatlas.org) and authors should follow the MIAPE recommendations (http://www.psidev.info/index.php?q=node/91).

Molecular interaction data should be deposited with a member of the International Molecular Exchange Consortium (IMEx, http://www.imexconsortium.org) prior to submission of the manuscript. Authors should follow the MIMIx recommendations (http://www.psidev.info/index.php?q=node/278).

Sequence data

Nucleotide sequence data should be submitted to an International Nucleotide Sequence Database Collaboration member: GenBank (http://www.ncbi.nlm.nih.gov/genbank/), EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl/) or DDBJ (http://www.ddbj.nig.ac.jp/).

Computational models

Computational models should be provided in a machine-readable form at submission stage to allow reviewers to reproduce the analysis and simulations performed in the study. When possible, standardize format (SBML, CellML) should be used instead of scripts (e.g. MATLAB). Authors are strongly encouraged to follow the MIRIAM guidelines (http://biomodels.net/miriam/) and deposit their model in a public database such as Biomodels (http://biomodels.net/) or JWS Online (http://jjj.mib.ac.uk/).

Human clinical and genomic datasets

Molecular Systems Biology encourages authors to provide access to genotype and clinical data with as few restrictions as possible while respecting ethical obligations to the patients and relevant medical and legal issues. If practically possible and compatible with the individual consent agreement used in the study, such data should be deposited in one of the major public access-controlled repositories such as dbGAP (http://www.ncbi.nlm.nih.gov/gap) or EGA (http://www.ebi.ac.uk/ega). Simple genetic polymorphisms should be submitted to dbSNP (http://www.ncbi.nlm.nih.gov/SNP/).

Structural data

Molecular Systems Biology accepts and follows the recommendations of the International Union of Crystallography (IUCr), with regard to the deposition and release of macromolecular structural data. These guidelines are set out in the article by the IUCr Commission on Biological Macromolecules in Acta Crystallographica (2000), D56, 2. In summary, they state that all publications must be accompanied by deposition of both the atomic coordinates and the structure-factor amplitudes in the appropriate database (PDB or NDB). In the case of low-resolution structures for which only a chain trace is reported, a set of C alpha positions and structure-factor amplitudes may be sufficient.

For NMR structures, data deposited should include resonance assignments, and all restraints used in structure determination (NOEs, spin-spin coupling constants, amide exchange rates, etc) and the derived atomic coordinates for both an individual structure and for a family of acceptable structures.

Structures of biological macromolecules solved by electron microscopy must be submitted to the EMDB database at http://emdatabank.org. For a brief description of the database, see Lawson et al. (2011) Nucleic Acids Res. 39: D456-D464.

Submission

Presubmission Enquiries

If you have already prepared a manuscript, please submit this via our online system as an article, rather than sending a presubmission enquiry. This allows the editors to make a more informed decision as to whether or not the manuscript is potentially appropriate for the journal.

Presubmission can nevertheless be submitted to enquire whether a manuscript in preparation is likely to be of interest to the journal. Presubmission enquiries should be submitted via our online submission system (http://msb.msubmit.net) or by e-mail (msb@embo.org) and should minimally include a list of all authors, a cover letter and an abstract.

How to Submit

We use an online manuscript submission and tracking system: http://msb.msubmit.net

In order to submit, you must have registered for an account. After this, please consult the following instructions for submission via our secure server. Please be sure that your browser is set to accept cookies. Our tracking system requires cookies for proper operation.

For original submissions, you will need to upload a cover letter, a Word file of the text of the manuscript (including figure legends), and a PDF file containing all the figures. Alternatively, individual figure files can be uploaded separately but please note that this can be more time-consuming than a PDF submission. Additional Expanded View files can also be uploaded when applicable (please refer to the section ‘Expanded View’ above).

Once you have submitted your files and the conversion is in progress, it can take up to 30 minutes before the PDF, created in the conversion process, is ready for approval. Please contact the editorial office [msb@embo.org] if the conversion engine takes longer than this. It is important to check the quality of the figures in the converted PDF before approving the submission. Please remember that your manuscript will not be submitted until you have approved the converted files.

To avoid any unnecessary delays, please refer to the most current electronic formatting guidelines when preparing your manuscript for submission. Authors using computer systems with non-Western type encoding are strongly encouraged to eliminate all occurrences of non-standard fonts in both the manuscript and the figures. We suggest using only the fonts Times, Symbol, Courier and Helvetica.

We will acknowledge receipt of a submitted manuscript by e-mail as soon as the quality check (appropriate manuscript format and image quality) has been completed. All further correspondence will also be by e-mail. Please ensure that your servers are set up to allow e-mails from the journal, and contact us if you do not receive an acknowledgement e-mail within a few days of submission.

Manuscript Status

You can check the status of your manuscript at any time in the review process by:

  1. Accessing the system with your password or link sent to you in the acknowledgement e-mail.
  2. Clicking on the link represented by your manuscript tracking number and abbreviated title.
  3. Clicking on the “Check Status” link at the bottom of the displayed page.

This procedure will display tracking information about where your manuscript is in the submission/peer review process.

Please feel free to contact the editorial office [msb@embo.org] with status queries.

Submission of Revisions

When a manuscript is returned to authors for revision, the revised version should be submitted within three months of the authors’ receipt of the referee reports, unless another date is specified in the decision letter. Please contact the editor by the deadline in cases where extra time is required for revision. Additional time may be granted upon request at the Editors’ discretion, assuming the conceptual advance of the study stands (with regard to the current literature). As a matter of policy, we do not consider any competing manuscripts published during the specified revision period as negatively impacting on the conceptual advance presented by your study. However, we request that you contact the editor as soon as possible upon publication of any related work, to discuss how to proceed.

Only a single round of revision is generally permitted.

The initial decision letter on the original version of the manuscript provides a URL that should be used for submission of revised manuscripts. Please do not upload revisions as new submissions.

Revisions should be accompanied by a point-by-point response to the referees’ comments as well as the editorial decision letter, in PDF or Word format. To facilitate the re-evaluation, we encourage authors to intercalate their response with the referee comments.

In addition, the following items are required when submitting a revision:

  1. The manuscript text in LaTeX, RTF or MS Word format.
  2. A letter with a detailed description of the changes made in response to the referees.
  3. Three to four "bullet points" highlighting the main findings of your study.
  4. A "standfirst text" summarizing the study in one or two sentences (approximately 250 characters). Bullet points and standfirst text should be submitted as a separate manuscript file in LaTeX, RTF or MS Word format.
  5. A "thumbnail image" (211x157 pixels, jpeg format) to highlight the paper on our homepage.

For Acceptance and Publication

Before acceptance and transfer to our publishers, manuscripts will be checked for appropriate formatting and image processing, and for plagiarism. We cannot proceed to acceptance until data are available in public databases when required; see above for details.

Proofs

Authors will be sent an e-mail with a link to ownload their proof. The PDF should be clearly annotated for necessary corrections and then returned by e-mail. It is the authors’ responsibility to check that the final proof is accurate. In the interests of speed, corrections should be returned within 24 hours. Essential changes of an extensive nature may be made only by insertion of a ‘Note added in proof’, and only with the approval of the Editors. A charge will be made to authors who insist on extensive amendment within the text at the page proof stage. Excessive alterations may delay publication of the article.

Press Embargo

When discussing unpublished data (including data in accepted papers not yet published) with the press, authors should take care not to break the journal embargo policy (see above for details).

Open Access and Charges

Molecular Systems Biology levies an article publication charge of 3,000 EUROS (3,900 USD) per article accepted for publication (Research Articles, Reports, non-commissioned Reviews and Perspectives). There are no additional costs (such as page charges or submission charges).

Commissioned articles are free of any publication charges.

Upon acceptance, the corresponding author will receive instructions by email for completing the relevant license forms and payments. We will automatically waive or discount charges for corresponding authors working in countries covered by the Research4Life Initiative (see the Wiley Open Access Waiver Country List. In exceptional circumstances charges may be reduced for authors that can provide evidence that they are unable to pay the fees.

Processing of an accepted manuscript for publication can only proceed once the charge payment form and licence to publish have been completed.

Authors who receive funding from an agency or institution with a Wiley Open Access Account do not pay directly. The charge is paid by the institution or funder. Authors whose institutions have paid the Wiley Open Access partner fee are eligible for a discount on the publication charge and on acceptance a discounted fee is payable by the author. Please see additional details on the payment form.

Molecular Systems Biology articles are freely accessible to all via the Internet and are also deposited immediately upon publication, without embargo, to the Open Access repository PubMed Central.

Copyright on any article published by Molecular Systems Biology is retained by the author(s).

Molecular Systems Biology articles are published under the Creative Commons Attribution CC BY 4.0 License. This license permits users to access, download, copy, display and redistribute Molecular Systems Biology articles, as well as adapt, translate, text- and data-mine the content subject to the following conditions:

  • The authors' moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation or integrity may be impugned).
  • If article content is copied, downloaded or otherwise reused, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI and the link to the definitive published version) should be maintained. Copyright notices and disclaimers must not be deleted.
  • Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.

Please note that any file labeled “Source Data”, “Dataset” or “Resource” is released under a Creative Commons CC0 1.0 Universal Licence. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

Digital Object Identifier

EMBO Press and its publishing partners assign a unique digital object identifier (DOI) to every article it publishes. The DOI initiative is an international effort for electronic content identification and is guided by the International DOI Foundation, composed primarily of academic publishers and societies. The DOI appears on the title page of the article. It is assigned after the article has been accepted for publication and persists throughout the lifetime of the article. It is important to include the article’s DOI in the reference, as volume and page information is not always available for articles published online.

Help and Contact

If you need additional help, you can click on the help signs (icon) spread throughout the system. A help dialogue will pop up with context sensitive help. For questions regarding our policies and guidelines, please contact Molecular Systems Biology editorial office (msb@embo.org).